Title : Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro.

Pub. Date : 2000 Oct

PMID : 11256231






2 Functional Relationships(s)
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1 The maximum ChE inhibition by physostigmine developed within 30-60 min, while the inhibitory effect of rivastigmine on AChE and BuChE activities reached its peak after 48 and 6 h, respectively. Rivastigmine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 The order of inhibitory potency (IC50) towards AChE activity under optimal assay conditions for each ChE inhibitor was: physostigmine (0.67 nM) > rivastigmine (4.3 nM) > donepezil (6.7 nM) > TAK-147 (12 nM) > tacrine (77 nM) > ipidacrine (270 nM). Rivastigmine acetylcholinesterase (Cartwright blood group) Homo sapiens