Title : Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model.

Pub. Date : 2001 Mar

PMID : 11254667






1 Functional Relationships(s)
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1 Here we show that induction of HHcy in apoE-null mice by a diet enriched in methionine but depleted in folate and vitamins B6 and B12 increased atherosclerotic lesion area and complexity, and enhanced expression of receptor for advanced glycation end products (RAGE), VCAM-1, tissue factor, and MMP-9 in the vasculature. Folic Acid apolipoprotein E Mus musculus