Title : Interaction of fluorescence probes with acetylcholinesterase. The site and specificity of propidium binding.

Pub. Date : 1975 May 6

PMID : 1125207






2 Functional Relationships(s)
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1 A bis-quaternary fluorescence probe, propidium diiodide, has been found to exhibit a tenfold enhancement of fluorescence when bound to acetylcholinesterase from Torpedo california. Propidium acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Although propidium and edrophonium associate at separate sites on acetylcholinesterase, bis-quaternary ligands where the quaternary nitrogens are separated by 14 A displace both ligands from the enzyme with equal effectiveness. Propidium acetylcholinesterase (Cartwright blood group) Homo sapiens