Title : An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

Pub. Date : 2001 Mar 13

PMID : 11248086






2 Functional Relationships(s)
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1 By using combinations of knockout and transgenic animals, we show that activation of SXR/PXR is necessary and sufficient to both induce CYP3A enzymes and confer resistance to toxicity by LCA, as well as other xenotoxicants such as tribromoethanol and zoxazolamine. Zoxazolamine nuclear receptor subfamily 1 group I member 2 Homo sapiens
2 By using combinations of knockout and transgenic animals, we show that activation of SXR/PXR is necessary and sufficient to both induce CYP3A enzymes and confer resistance to toxicity by LCA, as well as other xenotoxicants such as tribromoethanol and zoxazolamine. Zoxazolamine nuclear receptor subfamily 1 group I member 2 Homo sapiens