Pub. Date : 2001 Mar 13
PMID : 11248085
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. | Lithocholic Acid | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | In this study, we demonstrate that PXR is activated by the toxic bile acid lithocholic acid (LCA) and its 3-keto metabolite. | Lithocholic Acid | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 3 | In this study, we demonstrate that PXR is activated by the toxic bile acid lithocholic acid (LCA) and its 3-keto metabolite. | Lithocholic Acid | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 4 | Finally, we demonstrate that activation of PXR protects against severe liver damage induced by LCA. | Lithocholic Acid | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 5 | Based on these data, we propose that PXR serves as a physiological sensor of LCA, and coordinately regulates gene expression to reduce the concentrations of this toxic bile acid. | Lithocholic Acid | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |