Title : Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase.

Pub. Date : 2001 Feb 15

PMID : 11245472






2 Functional Relationships(s)
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Protein Name
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1 Stable expression of a dominant negative mutant of ERK2 or p38 kinase or their respective inhibitor, PD98059 or SB202190, repressed the phosphorylation of p53 at serine 15. Serine mitogen-activated protein kinase 1 Homo sapiens
2 These data strongly suggest that both ERKs and p38 kinase mediate resveratrol-induced activation of p53 and apoptosis through phosphorylation of p53 at serine 15. Serine mitogen-activated protein kinase 1 Homo sapiens