Pub. Date : 2001 Feb 15
PMID : 11245459
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). | vadimezan | chemokine (C-X-C motif) ligand 10 | Mus musculus |
| 2 | Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). | vadimezan | chemokine (C-X-C motif) ligand 10 | Mus musculus |
| 3 | The genes for IFN-alpha and for interferon-inducible protein 10 (IP-10) were strongly induced in both spleen and Colon 38 tumor tissue after DMXAA treatment, whereas that for IFN-gamma was induced in spleen but not in tumor. | vadimezan | chemokine (C-X-C motif) ligand 10 | Mus musculus |
| 4 | The genes for IFN-alpha and for interferon-inducible protein 10 (IP-10) were strongly induced in both spleen and Colon 38 tumor tissue after DMXAA treatment, whereas that for IFN-gamma was induced in spleen but not in tumor. | vadimezan | chemokine (C-X-C motif) ligand 10 | Mus musculus |
| 5 | Antibodies to IP-10 reversed the inhibition of DMXAA of endothelial cell invasion by 58%; antibodies to tumor necrosis factor-alpha, IFN-gamma, and IFN-alpha reversed inhibition by 7%, 5%, and 0%, respectively. | vadimezan | chemokine (C-X-C motif) ligand 10 | Mus musculus |
| 6 | The data support the hypothesis that DMXAA, in addition to antivascular effects mediated by tumor necrosis factor-alpha, may have an antiangiogenic effect mediated largely by the induction of IP-10. | vadimezan | chemokine (C-X-C motif) ligand 10 | Mus musculus |