Title : [A study on the tumor suppressing effect of a specific point mutant p53 minigene in the expression regulated model with a tetracycline-transactivative response promoter].

Pub. Date : 1998 Oct

PMID : 11245004






4 Functional Relationships(s)
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Protein Name
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1 [A study on the tumor suppressing effect of a specific point mutant p53 minigene in the expression regulated model with a tetracycline-transactivative response promoter]. Tetracycline tumor protein p53 Homo sapiens
2 OBJECTIVE: To establish a tetracycline-regulated expression model and to determine and verify whether a specific point mutant type p53 minigene, containing an Arg-->Leu substitution at amino acid 172, possesses a suppressing effect on human lung cancer. Tetracycline tumor protein p53 Homo sapiens
3 Then the specific p53 minigene was sub-cloned into a tetracycline-transactivative controlled expression vector pBPSTR1 by gene recombination methods. Tetracycline tumor protein p53 Homo sapiens
4 The tetracycline transactivative p53 minigene-regulated transgene model was successfully established. Tetracycline tumor protein p53 Homo sapiens