Title : Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors.

Pub. Date : 2001 Mar 15

PMID : 11238657






4 Functional Relationships(s)
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1 In the present study histamine (10(-9)-10(-6) M) increased in a concentration-dependent fashion the basal release of beta-glucuronidase (EC(50) = 8.2 +/- 3.5 x 10(-9) M) and IL-6 (EC(50) = 9.3 +/- 2.9 x 10(-8) M) from human lung macrophages. Histamine glucuronidase beta Homo sapiens
2 Enhancement of beta-glucuronidase release induced by histamine was evident after 30 min and peaked at 90 min, whereas that of IL-6 required 2-6 h of incubation. Histamine glucuronidase beta Homo sapiens
3 Histamine-induced beta-glucuronidase and IL-6 release and [Ca(2+)](i) elevation were inhibited by the selective H(1) antagonist fexofenadine (10(-7)-10(-4) M), but not by the H(2) antagonist ranitidine. Histamine glucuronidase beta Homo sapiens
4 Inhibition of histamine-induced beta-glucuronidase and IL-6 release by fexofenadine was concentration dependent and displayed the characteristics of a competitive antagonism (K(d) = 89 nM). Histamine glucuronidase beta Homo sapiens