Pub. Date : 1999 Summer
PMID : 11228745
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arachidonic acid metabolites mediate angiotensin II-induced NADH/NADPH oxidase activity and hypertrophy in vascular smooth muscle cells. | Arachidonic Acid | angiotensinogen | Homo sapiens |
| 2 | Angiotensin II stimulates phospholipase A2, releasing arachidonic acid, which stimulates oxidase activity in vitro. | Arachidonic Acid | angiotensinogen | Homo sapiens |
| 3 | Attenuation of oxidase activation by inhibiting arachidonic acid metabolism with ETYA, NDGA, baicalein, or SKF-525A also inhibits angiotensin II-stimulated protein synthesis (74 +/- 2% and 34 +/- 1%, respectively). | Arachidonic Acid | angiotensinogen | Homo sapiens |
| 4 | Thus, endogenous noncyclooxygenase arachidonic acid metabolites mediate angiotensin II-stimulated protein synthesis in cultured VSMC by activating the NADH/NADPH oxidase, providing mechanistic evidence for redox control of VSMC hypertrophy. | Arachidonic Acid | angiotensinogen | Homo sapiens |