Title : Experimental targeted radioiodide therapy following transfection of the sodium iodide symporter gene: effect on clonogenicity in both two-and three-dimensional models.

Pub. Date : 2000 Dec

PMID : 11228531






2 Functional Relationships(s)
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1 To evaluate the potential of the expression of the sodium/iodide symporter (NIS) as a means of targeting radioiodine to tumor cells, we have employed plasmid-mediated transfection of the NIS gene into a range of mammalian cell hosts. Iodine-131 solute carrier family 5 member 5 Homo sapiens
2 After exposure of two-dimensional monolayer cultures of UVW-NIS cells to 131I- at a radioactive concentration of 4 MBq/mL, clonogenic survival was reduced to 21%. Iodine-131 solute carrier family 5 member 5 Homo sapiens