Title : In vitro based index of topical anti-inflammatory activity to compare a series of NSAIDs.

Pub. Date : 2001 Mar

PMID : 11226820






2 Functional Relationships(s)
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1 The pharmacodynamic aspect, based on the ability to inhibit cyclooxygenase-2 (COX-2) in vitro, was determined by incubating human dermal fibroblasts in culture, pre-treated with phobol-12-myristate-13-acetate (PMA) for 6 h, with 25 microM [(14)C]-arachidonic acid (AA) in the presence of several drug concentrations. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
2 The pharmacodynamic aspect, based on the ability to inhibit cyclooxygenase-2 (COX-2) in vitro, was determined by incubating human dermal fibroblasts in culture, pre-treated with phobol-12-myristate-13-acetate (PMA) for 6 h, with 25 microM [(14)C]-arachidonic acid (AA) in the presence of several drug concentrations. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens