Pub. Date : 2000 Oct
PMID : 11213533
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | L-carnitine reduces plasma lipoprotein(a) levels in patients with hyper Lp(a). | Carnitine | lipoprotein(a) | Homo sapiens |
| 2 | METHODS AND RESULTS: L-carnitine, a natural compound stimulating fatty acid oxidation at the mitochondrial level, was tested in a double blind study in 36 subjects with Lp(a) levels ranging between 40-80 mg/dL, in most with concomitant LDL cholesterol and triglyceride elevations. | Carnitine | lipoprotein(a) | Homo sapiens |
| 3 | L-carnitine (2 g/day) significantly reduced Lp(a) levels (-7.7% vs baseline and -11.7% vs placebo treatment), the reduction being more dramatic in the subjects with the more marked elevations. | Carnitine | lipoprotein(a) | Homo sapiens |
| 4 | In particular, in the L-carnitine group, 14 out of 18 subjects (77.8%) had a significant reduction of Lp(a) vs only 7 out of 18 (38.9%) in the placebo group (chi 2 = 4.11, p = 0.0452). | Carnitine | lipoprotein(a) | Homo sapiens |
| 5 | CONCLUSIONS: L-carnitine offers a potentially useful therapeutic agent for atherogenic conditions characterized by high Lp(a) levels, also in view of the excellent tolerability and essential lack of major side effects. | Carnitine | lipoprotein(a) | Homo sapiens |