Title : Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation.

Pub. Date : 2000 Winter

PMID : 11213488






9 Functional Relationships(s)
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1 We found that small proportions of c-Ret and Ret-MEN2B and a large proportion of MEN2A were dimerized due to disulfide bonds and that high kinase activity resided in these fractions. Disulfides ret proto-oncogene Homo sapiens
2 We found that small proportions of c-Ret and Ret-MEN2B and a large proportion of MEN2A were dimerized due to disulfide bonds and that high kinase activity resided in these fractions. Disulfides ret proto-oncogene Homo sapiens
3 We found that small proportions of c-Ret and Ret-MEN2B and a large proportion of MEN2A were dimerized due to disulfide bonds and that high kinase activity resided in these fractions. Disulfides ret proto-oncogene Homo sapiens
4 The UV-induced activation of c-Ret and superactivation of Ret-MEN2A and Ret-MEN2B were then shown to be closely associated with promotion of the disulfide bond-mediated dimerization of the Ret proteins. Disulfides ret proto-oncogene Homo sapiens
5 The UV-induced activation of c-Ret and superactivation of Ret-MEN2A and Ret-MEN2B were then shown to be closely associated with promotion of the disulfide bond-mediated dimerization of the Ret proteins. Disulfides ret proto-oncogene Homo sapiens
6 The UV-induced activation of c-Ret and superactivation of Ret-MEN2A and Ret-MEN2B were then shown to be closely associated with promotion of the disulfide bond-mediated dimerization of the Ret proteins. Disulfides ret proto-oncogene Homo sapiens
7 The UV-induced activation of c-Ret and superactivation of Ret-MEN2A and Ret-MEN2B were then shown to be closely associated with promotion of the disulfide bond-mediated dimerization of the Ret proteins. Disulfides ret proto-oncogene Homo sapiens
8 The UV-induced activation of c-Ret and superactivation of Ret-MEN2A and Ret-MEN2B were then shown to be closely associated with promotion of the disulfide bond-mediated dimerization of the Ret proteins. Disulfides ret proto-oncogene Homo sapiens
9 The UV-induced activation of c-Ret and superactivation of Ret-MEN2A and Ret-MEN2B were then shown to be closely associated with promotion of the disulfide bond-mediated dimerization of the Ret proteins. Disulfides ret proto-oncogene Homo sapiens