Pub. Date : 2001 Jan 15
PMID : 11212259
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human papillomavirus type 16 E6 inactivation of p53 in normal human mammary epithelial cells promotes tamoxifen-mediated apoptosis. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 2 | Early passage p53(-) HMEC-E6-transduced cells treated with 1.0 microM tamoxifen rapidly underwent apoptosis. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 3 | In contrast, early passage p53(+) HMEC-LXSN vector controls treated with 1.0 microM tamoxifen underwent G1-G0-phase arrest but did not undergo apoptosis. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 4 | p53(-) HMEC-E6 cells rapidly acquired resistance to tamoxifen-mediated apoptosis after 10 passages in culture (in the absence of tamoxifen). | Tamoxifen | tumor protein p53 | Homo sapiens |
| 5 | Tamoxifen-mediated apoptosis in p53(-) HMEC-E6 cells was not blocked by inhibitors of transcription and protein synthesis. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 6 | These data suggest that the acute loss of p53 function in HMECs by expression of HPV-16 E6 results in marked sensitivity to tamoxifen-mediated apoptosis but that resistance to apoptosis rapidly develops within 10 passages in vitro. | Tamoxifen | tumor protein p53 | Homo sapiens |