Title : Protein kinase C activation by 12-0-tetradecanoylphorbol 13-acetate in CG-4 line oligodendrocytes stimulates turnover of choline and ethanolamine phospholipids by phospholipase D and induces rapid process contraction.

Pub. Date : 2001 Jan

PMID : 11208899






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Ro31-8220, a PKC inhibitor, reduced TPA-stimulated release of choline- and ethanolamine-metabolites to basal levels. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus
2 Exposure of bipolar undifferentiated CG-4 line cells to TPA resulted in down-regulatation of PKC-alpha and PKC-beta which could not be detected by Western blotting after a few hours; PKC-epsilon was down-regulated much more slowly but PKCs delta, zeta and iota were not influenced by 48 h exposure of cells to TPA. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus