Title : Role of Cyclooxygenase-2-Derived Metabolites and NO in Renal Response to Bradykinin.

Pub. Date : 2001 Jan

PMID : 11208767






4 Functional Relationships(s)
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1 -It has been reported that bradykinin (BK) can induce or activate both cyclooxygenase (COX) isoforms and that the renal effects of BK seem to be mediated by prostaglandins and NO. Prostaglandins kininogen 1 Canis lupus familiaris
2 -It has been reported that bradykinin (BK) can induce or activate both cyclooxygenase (COX) isoforms and that the renal effects of BK seem to be mediated by prostaglandins and NO. Prostaglandins kininogen 1 Canis lupus familiaris
3 -It has been reported that bradykinin (BK) can induce or activate both cyclooxygenase (COX) isoforms and that the renal effects of BK seem to be mediated by prostaglandins and NO. Prostaglandins kininogen 1 Canis lupus familiaris
4 The results of this study suggest that (1) NO and prostanoids dependent on COX-2 seem to be involved in the renal vasodilatation induced by BK, and (2) there is an interaction between NO and COX-1-derived metabolites in mediating the natriuretic and diuretic response to BK. Prostaglandins kininogen 1 Canis lupus familiaris