Title : pH regulation in isolated in vitro perfused rat colonic crypts.

Pub. Date : 2000 Nov

PMID : 11205049






2 Functional Relationships(s)
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1 The physiological concentrations of both luminal CO2/HCO3- and acetic acid/acetate acidified pHi significantly, but less than when applied from the basolateral side. Bicarbonates glucose-6-phosphate isomerase Rattus norvegicus
2 The basolateral transporters involved in pHi recovery are probably the EIPA- and HOE694-inhibitable (IC50=0.2 and 2 micromol/l, respectively) Na+/H+ exchanger NHE1 and the DIDS-inhibitable Na+-dependent HCO3- importer. Bicarbonates glucose-6-phosphate isomerase Rattus norvegicus