Title : Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor.

Pub. Date : 2000 Dec

PMID : 11192947






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We conclude that 1) neutralization of HGF and gastrin by their specificantibodies delays ulcer healing due fall in the microcirculation around the ulcer and a decrease in the COX-2 expression, 2) COX-2 derived prostaglandins may play an important role in acceleration of the ulcer healing by various growth factors including HGF and gastrin, 3) enhancement of the local pool for growth factors such as HGF and gastrin at the ulcer site could offer a new modality for treatment of gastric ulcer. Prostaglandins cytochrome c oxidase II, mitochondrial Rattus norvegicus