Title : Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons.

Pub. Date : 2001 Jan

PMID : 11191832






1 Functional Relationships(s)
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1 A potent inhibitor of kynurenine 3-hydroxylase, PNU 156561A (40 mg/kg, i.v., 4-7 h), was utilized to increase the levels of kynurenic acid in rat brain. Kynurenic Acid kynurenine 3-monooxygenase Rattus norvegicus