Pub. Date : 2001 Mar
PMID : 11181491
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of bacterial lipopolysaccharide on phenobarbital-induced CYP2B expression in mice. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 2 | The effects of LPS on expression of phenobarbital (PB)-induced CYP2B1/2 in rats have been well characterized, but less is known about the effects of LPS on PB-induced CYP2B in mice. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 3 | The effects of LPS on expression of phenobarbital (PB)-induced CYP2B1/2 in rats have been well characterized, but less is known about the effects of LPS on PB-induced CYP2B in mice. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 4 | Since genetically manipulated mice represent an attractive model to study the mechanisms involved in the down-regulation of CYP2B expression by LPS, we investigated the effects of LPS on PB-induced CYP2B expression in mouse liver. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 5 | LPS inhibited the mRNA expression of CYP2B10 and CYP2B9 at 6 and 12 h of treatment, with the inhibitory effect more profound at 12 h. LPS also suppressed the CYP2B9 mRNA level at 24 h. However, CYP2B10 mRNA levels in mice treated with PB alone had declined markedly by 24 h after the last PB injection; therefore, no effect of LPS could be discerned. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 6 | LPS inhibited the mRNA expression of CYP2B10 and CYP2B9 at 6 and 12 h of treatment, with the inhibitory effect more profound at 12 h. LPS also suppressed the CYP2B9 mRNA level at 24 h. However, CYP2B10 mRNA levels in mice treated with PB alone had declined markedly by 24 h after the last PB injection; therefore, no effect of LPS could be discerned. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 7 | This study suggests that LPS suppresses the expression of phenobarbital-induced CYP2B expression in mice, which resembles its effects in rats. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |