Title : Phosphorylation of connexin43 and inhibition of gap junctional communication in 12-O-tetradecanoylphorbol-13-acetate-exposed R6 fibroblasts: minor role of protein kinase C beta I and mu.

Pub. Date : 2001 Feb

PMID : 11181442






2 Functional Relationships(s)
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1 Thus, total PKC activity does not indicate absolute sensitivity of a cell system to TPA-induced suppression of communication, but within a certain cell system increasing PKC activity may enhance the sensitivity to TPA in this respect. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus
2 Long-term treatment with TPA caused strong down-regulation of PKC alpha, delta and epsilon, but little down-regulation of PKC mu. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus