Title : High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells.

Pub. Date : 2001 Feb

PMID : 11168928






3 Functional Relationships(s)
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1 PKC activator phorbol 12-myristate 13-acetate (PMA) induced 2.2- and 1.4-fold increase in TGF-beta 1 and FN mRNA expression, respectively. Tetradecanoylphorbol Acetate fibronectin 1 Homo sapiens
2 PKC activator phorbol 12-myristate 13-acetate (PMA) induced 2.2- and 1.4-fold increase in TGF-beta 1 and FN mRNA expression, respectively. Tetradecanoylphorbol Acetate fibronectin 1 Homo sapiens
3 Depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and high glucose-induced, but not constitutive, expression of TGF-beta 1 and FN. Tetradecanoylphorbol Acetate fibronectin 1 Homo sapiens