Title : The effect of folate deficiency on the cytotoxic and mutagenic responses to ethyl methanesulfonate in human lymphoblastoid cell lines that differ in p53 status.

Pub. Date : 2001 Jan 25

PMID : 11166026






1 Functional Relationships(s)
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1 Treatment of folate-replete or deficient WTK1 and TK6 cells with increasing concentrations (0-50microg/ml) of ethyl methanesulfonate (EMS) resulted in significantly different HPRT mutation dose-response relationships (P<0.01), indicating that folate deficiency increased the EMS-induced mutant frequency in both cell lines, but with a greater effect in TK6 cells. Ethyl Methanesulfonate hypoxanthine phosphoribosyltransferase 1 Homo sapiens