Pub. Date : 2000 Nov
PMID : 11164086
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 2 | To evaluate the role of the 5-HT1B receptor in mediating the actions of cocaine, we used two model systems: knockout (KO) mice lacking the 5-HT1B receptor and an acute treatment with the 5-HT1B/1D antagonist GR127935. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 3 | To evaluate the role of the 5-HT1B receptor in mediating the actions of cocaine, we used two model systems: knockout (KO) mice lacking the 5-HT1B receptor and an acute treatment with the 5-HT1B/1D antagonist GR127935. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 4 | In contrast, as demonstrated previously, the 5-HT1B receptor KO mice showed a heightened locomotor response to cocaine, as well as an increased propensity to self-administer cocaine. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 5 | In contrast, as demonstrated previously, the 5-HT1B receptor KO mice showed a heightened locomotor response to cocaine, as well as an increased propensity to self-administer cocaine. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 6 | Thus, an acute pharmacological blockade of the 5-HT1B receptor decreases some effects of cocaine, while a constitutive genetic KO of the same receptor has opposite effects. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 7 | These results suggest that compensatory changes have taken place during the development of the 5-HT1B KO mice, which may have rendered these mice more vulnerable to cocaine. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |