Pub. Date : 2001 Jan 26
PMID : 11162588
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously shown that interferon-alpha (IFN alpha)-dependent tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) is impaired by serine phosphorylation of IRS-1 due to the reduced ability of serine phosphorylated IRS-1 to serve as a substrate for Janus kinase 1 (JAK1). | Tyrosine | interferon alpha 1 | Homo sapiens |
| 2 | Furthermore, treatment of U266 cells with the FRAP inhibitor rapamycin increased IFN alpha-dependent tyrosine phosphorylation by twofold while reducing constitutive IRS-1 serine phosphorylation within S/T-P motifs by 80%. | Tyrosine | interferon alpha 1 | Homo sapiens |