Title : Modulation of P450 CYP3A4-dependent metabolism by P-glycoprotein: implications for P450 phenotyping.

Pub. Date : 2001 Feb

PMID : 11160617






1 Functional Relationships(s)
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1 In cultured cells, the presence of pgp increased the apparent K(m) for the 6beta-hydroxylase activity of CYP3A4 toward testosterone and cortisol by a factor of 1.7 and 4, respectively. Testosterone ATP binding cassette subfamily B member 1 Homo sapiens