Pub. Date : 2001 Jan
PMID : 11159700
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. | rasagiline | monoamine oxidase B | Rattus norvegicus |
| 2 | The ED(50) values for ex vivo inhibition of MAO in the brain and liver by a single dose of rasagiline are 0.1+/-0.01, 0.042+/-0.0045 mg kg(-1) respectively for MAO-B, and 6.48+/-0.81, 2.38+/-0.35 mg kg(-1) respectively for MAO-A. | rasagiline | monoamine oxidase B | Rattus norvegicus |
| 3 | The degree of selectivity of rasagiline for inhibition of MAO-B as opposed to MAO-A was similar to that of selegiline. | rasagiline | monoamine oxidase B | Rattus norvegicus |
| 4 | Rasagiline was three to 15 times more potent than selegiline for inhibition of MAO-B in rat brain and liver in vivo on acute and chronic administration, but had similar potency in vitro. | rasagiline | monoamine oxidase B | Rattus norvegicus |