Title : Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons induce a functional switch in the growth factor responsiveness of astroglia: involvement of basic fibroblast growth factor.

Pub. Date : 2000 Dec

PMID : 11154844






1 Functional Relationships(s)
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Protein Name
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1 Pre-treatment of hypothalamic astrocytes with an inactive ("priming") dose of bFGF for 12 h powerfully increased astroglia proliferative response to IGF-I (10 ng/ml), EGF (10 g/ml) and insulin (10 microg/ml), inducing a 65-100% increase in the [3H]thymidine incorporation compared to untreated cultures. Thymidine fibroblast growth factor 2 Mus musculus