Title : Studies on the mechanism of the reaction between coenzyme B12 and cyanide: direct 1H NMR spectroscopic evidence for a (beta-5'-deoxyadenosyl)(alpha-cyano)cobalamin intermediate.

Pub. Date : 2000 Nov 27

PMID : 11154562






1 Functional Relationships(s)
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1 Under these conditions rate-determining Co-C heterolytic cleavage is preceded by rapid addition of cyanide to AdoCbl to form an intermediate, (beta-5"-deoxyadenosyl)(alpha-cyano)cobalamin ((beta-Ado)(alpha-CN)Cbl-), identified by 1H NMR spectroscopy. Hydrogen Cbl proto-oncogene Homo sapiens