Title : Studies on the mechanism of the reaction between coenzyme B12 and cyanide: direct 1H NMR spectroscopic evidence for a (beta-5'-deoxyadenosyl)(alpha-cyano)cobalamin intermediate.

Pub. Date : 2000 Nov 27

PMID : 11154562






3 Functional Relationships(s)
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1 Under these conditions rate-determining Co-C heterolytic cleavage is preceded by rapid addition of cyanide to AdoCbl to form an intermediate, (beta-5"-deoxyadenosyl)(alpha-cyano)cobalamin ((beta-Ado)(alpha-CN)Cbl-), identified by 1H NMR spectroscopy. Cyanides Cbl proto-oncogene Homo sapiens
2 A mechanism in 92% DMF/8% D2O is proposed which involves rapid reversible formation of (beta-Ado)(alpha-CN)Cbl- from base-off AdoCbl plus cyanide, followed by rate-determining solvent-assisted cleavage of the Co-C bond of the intermediate and subsequent rapid addition of a second cyanide to give the products. Cyanides Cbl proto-oncogene Homo sapiens
3 A mechanism in 92% DMF/8% D2O is proposed which involves rapid reversible formation of (beta-Ado)(alpha-CN)Cbl- from base-off AdoCbl plus cyanide, followed by rate-determining solvent-assisted cleavage of the Co-C bond of the intermediate and subsequent rapid addition of a second cyanide to give the products. Cyanides Cbl proto-oncogene Homo sapiens