Title : Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death.

Pub. Date : 2001 Jan

PMID : 11149897






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have identified some purines (hypoxanthine, inosine, and adenosine) as potential endogenous PARP inhibitors. Adenosine poly(ADP-ribose) polymerase 1 Homo sapiens
2 We have found that purines (hypoxanthine > inosine > adenosine) dose-dependently inhibited PARP activation in peroxynitrite-treated macrophages and also inhibited the activity of the purified PARP enzyme. Adenosine poly(ADP-ribose) polymerase 1 Homo sapiens
3 We have found that purines (hypoxanthine > inosine > adenosine) dose-dependently inhibited PARP activation in peroxynitrite-treated macrophages and also inhibited the activity of the purified PARP enzyme. Adenosine poly(ADP-ribose) polymerase 1 Homo sapiens