Title : Estimating the selective advantage of mutant p53 tumour cells to repeated rounds of hypoxia.

Pub. Date : 2001 Jan

PMID : 11146880






2 Functional Relationships(s)
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1 Under low levels of oxygen (hypoxia), cells expressing wild-type p53 undergo programmed cell death (apoptosis), whereas cells expressing mutations in the p53 gene may survive and express angiogenic growth factors that stimulate tumour vascularization. Oxygen tumor protein p53 Homo sapiens
2 In this paper a mathematical model is presented to investigate the effects of alternating periods of hypoxia and normoxia (normal oxygen levels) on a population of wild-type and mutant p53 tumour cells. Oxygen tumor protein p53 Homo sapiens