Title : Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonists.

Pub. Date : 2001 Jan 15

PMID : 11139385






3 Functional Relationships(s)
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1 To clarify whether fatty-acyl-CoAs interact directly with the LBDs of PPARalpha and PPARgamma, we performed a competition binding assay with radiolabelled KRP-297, a known dual agonist for these receptors. Acyl Coenzyme A peroxisome proliferator activated receptor alpha Homo sapiens
2 We show here that fatty-acyl-CoAs bind directly to PPARalpha and PPARgamma. Acyl Coenzyme A peroxisome proliferator activated receptor alpha Homo sapiens
3 These findings demonstrate that fatty-acyl-CoAs have a novel function in the signalling pathways of PPARalpha and PPARgamma. Acyl Coenzyme A peroxisome proliferator activated receptor alpha Homo sapiens