Pub. Date : 2001 Jan
PMID : 11125018
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The pharmacology of recombinant rodent VR1 and the endogenous rat VR1 was indistinguishable when measuring displacement of [125I]RTX binding (i.e., the following rank order of affinity was observed: RTX > I-RTX > olvanil > capsaicin > capsazepine). | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 2 | The pharmacology of recombinant rodent VR1 and the endogenous rat VR1 was indistinguishable when measuring displacement of [125I]RTX binding (i.e., the following rank order of affinity was observed: RTX > I-RTX > olvanil > capsaicin > capsazepine). | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 3 | Capsaicin and RTX induced large nondesensitizing currents in Xenopus laevis oocytes expressing VR1 (EC50 values were 1300 nM and 0.2 nM, respectively), whereas I-RTX induced no current per se at concentrations up to 10 microM. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |