Title : Decrease in epidermal CD44 expression as a potential mechanism for abnormal hyaluronate accumulation in superficial dermis in lichen sclerosus et atrophicus.

Pub. Date : 2000 Dec

PMID : 11121141






4 Functional Relationships(s)
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1 Decrease in epidermal CD44 expression as a potential mechanism for abnormal hyaluronate accumulation in superficial dermis in lichen sclerosus et atrophicus. hyaluronate CD44 molecule (Indian blood group) Homo sapiens
2 In this study we provide evidence that hyaluronate is accumulated in the superficial dermis of lichen sclerosus et atrophicus lesions, in particular by the use of human CD44 receptor globulin staining, which binds specifically to hyaluronate. hyaluronate CD44 molecule (Indian blood group) Homo sapiens
3 In this study we provide evidence that hyaluronate is accumulated in the superficial dermis of lichen sclerosus et atrophicus lesions, in particular by the use of human CD44 receptor globulin staining, which binds specifically to hyaluronate. hyaluronate CD44 molecule (Indian blood group) Homo sapiens
4 These results suggest that a decrease in CD44 in the keratinocytes may be correlated with an abnormal dermal accumulation of hyaluronate in the lesions of lichen sclerosus et atrophicus, and may play a pathogenetic role in this disease. hyaluronate CD44 molecule (Indian blood group) Homo sapiens