Title : Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells.

Pub. Date : 2000 Dec

PMID : 11116048






2 Functional Relationships(s)
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Protein Name
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1 Treatment with either SB203580 (inhibitor of p38 MAPK) or U0126 (inhibitor of the ERK pathway) downregulated the TNF-alpha-induced MMP-9 expression in a dose-dependent manner. U 0126 matrix metallopeptidase 9 Rattus norvegicus
2 Furthermore, suboptimal inhibitory concentrations of SB203580 and U0126 together almost completely inhibited the MMP-9 expression. U 0126 matrix metallopeptidase 9 Rattus norvegicus