Title : Distinct inhibition of acute cocaine-stimulated motor activity following microinjection of a group III metabotropic glutamate receptor agonist into the dorsal striatum of rats.

Pub. Date : 2000 Sep

PMID : 11113488






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 However, pretreatment with L-AP4 (10 and 100 nmol) dose dependently blocked hyperlocomotion induced by acute injection of cocaine (20 mg/kg, i.p. Cocaine replication initiator 1 Rattus norvegicus
2 The behavioral activity induced by cocaine was much more sensitive to L-AP4 than that induced by amphetamine and apomorphine. Cocaine replication initiator 1 Rattus norvegicus
3 At 100 nmol, L-AP4 completely blocked cocaine effect whereas amphetamine- and apomorphine-stimulated behaviors were blocked only by 28% and 31%, respectively. Cocaine replication initiator 1 Rattus norvegicus
4 The blocking effect of L-AP4 on cocaine action was reversed by pretreatment with MPPG. Cocaine replication initiator 1 Rattus norvegicus