Title : Induced expression of dominant-negative c-jun downregulates NFkappaB and AP-1 target genes and suppresses tumor phenotype in human keratinocytes.

Pub. Date : 2000 Nov

PMID : 11108661






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 When a tetracycline-regulatable dominant-negative c-jun (TAM67, having a truncated transactivation domain) was expressed in tumorigenic human keratinocytes, AP-1- and NFkappaB- but not p53-dependent reporter activity was inhibited by 40-60%. Tetracycline Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 When a tetracycline-regulatable dominant-negative c-jun (TAM67, having a truncated transactivation domain) was expressed in tumorigenic human keratinocytes, AP-1- and NFkappaB- but not p53-dependent reporter activity was inhibited by 40-60%. Tetracycline Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens