Title : Cross-talk between interleukin 1beta (IL-1beta) and IL-6 signalling pathways: IL-1beta selectively inhibits IL-6-activated signal transducer and activator of transcription factor 1 (STAT1) by a proteasome-dependent mechanism.

Pub. Date : 2000 Dec 15

PMID : 11104703






1 Functional Relationships(s)
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1 However, pretreatment with the proteasome inhibitor MG132 under conditions that prevented the IL-1beta-dependent activation of the nuclear factor NF-kappaB also blocked the inhibitory effect of IL-1beta on IL-6-activated STAT1. benzyloxycarbonylleucyl-leucyl-leucine aldehyde interleukin 6 Homo sapiens