Title : Mechanism of the effects of hypothalamic deafferentation on prolactin secretion in the rat.

Pub. Date : 1975 Jan

PMID : 1109897






2 Functional Relationships(s)
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1 Posterolateral deafferentation was as effective as complete deafferentation in preventing the stress-induced prolactin release, whereas anterior frontal deafferentation had only a small effect, L-Dopa (100 mg/kg body wt, ip) decreased prolactin titers in both control and deafferented animals, whereas reserpine (1 mg/kg body wt, ip) had the opposite effect. Levodopa prolactin Rattus norvegicus
2 Since both drugs inhibited prolactin release from pituitaries in vitro, the decrease of prolactin levels following L-dopa in vivo might have been caused not only by stimulation of PIF release but also at least partly by the direct effect of the drug on the pituitary. Levodopa prolactin Rattus norvegicus