Title : The effect of galactose metabolic disorders on rat brain acetylcholinesterase activity.

Pub. Date : 2000 Sep-Oct

PMID : 11098845






1 Functional Relationships(s)
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1 To evaluate whether in classical galactosemia galactose (Gal), galactose-1-phosphate (Gal-1-P) and galactitol (Galtol) affect brain acetylcholinesterase (AChE) activity, various concentrations (1-16 mM) of these compounds were preincubated with brain homogenates of suckling rats as well as with pure eel Electroforus electricus AChE at 37 degrees C for 1 h. Initially, Galtol (up to 2.0 mM) increased (25%) AChE activity which decreased. Galactose acetylcholinesterase Rattus norvegicus