Pub. Date : 2000 Dec 5
PMID : 11095706
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 2 | The recently cloned rat vanilloid receptor, VR1, can be activated by capsaicin, acid, and heat. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 3 | Three of the mutant channels are significantly more sensitive to capsaicin than is wild-type VR1, whereas none differed in their activation by acidic pH or temperature. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 4 | These data indicate that VR1 undergoes conformational changes upon capsaicin binding that it does not undergo in response to activation by protons or thermal stimuli. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |