Title : Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells.

Pub. Date : 2000 Dec 1

PMID : 11090076






2 Functional Relationships(s)
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1 Treatment of human leukemic cells with etoposide, Ara-C, or doxorubicin increased DR5 but not DR4, Fas, DcR1, DcR2, Fas ligand, or Apo-2L levels. Etoposide TNF superfamily member 10 Homo sapiens
2 These findings indicate that treatment with etoposide, Ara-C, or doxorubicin up-regulates DR5 levels in a p53-independent manner and sensitizes human acute leukemia cells to Apo-2L-induced apoptosis. Etoposide TNF superfamily member 10 Homo sapiens