Title : The substrate specificity of the catalytic domain of Abl plays an important role in directing phosphorylation of the adaptor protein Crk.

Pub. Date : 2000 Oct

PMID : 11080615






2 Functional Relationships(s)
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1 c-Abl preferentially phosphorylates peptide substrates that contain proline at the P+3 site (relative to the phosphorylated tyrosine). Proline ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 In this study, we examine the phosphorylation of Crk, a protein substrate of Abl that is phosphorylated in the sequence Tyr221-Ala-Gln-Pro. Proline ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens