Title : Occurrence of an elongated p-Oxo ketene intermediate in the dissociative alkaline hydrolysis of aryl (2E, 4E)-5-(4'-Hydroxyphenyl)pentadienoates

Pub. Date : 2000 Nov 17

PMID : 11073588






1 Functional Relationships(s)
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1 Break in the Bronsted plot of the apparent second-order rate constants versus the pK(a) of the leaving group suggests that the reaction mechanism changes from E1cB to B(Ac)2 for esters having pK(a) higher than about 6. Esters adenylate cyclase 2 Homo sapiens