Title : Differential MMP and TIMP production by human marrow and peripheral blood CD34(+) cells in response to chemokines.

Pub. Date : 2000 Nov

PMID : 11063876






1 Functional Relationships(s)
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1 We found that an SDF-1 gradient increases the chemotaxis of BM and PB CD34(+) cells across Matrigel (BM > PB), which is blocked by inhibitors of MMPs (o-phenanthroline, rhTIMP-1, rhTIMP-2, and anti-MMP-9 and anti-MMP-2 antibodies) but enhanced by tumor necrosis factor-alpha (TNF-alpha), a strong stimulator of MMPs. 1,10-phenanthroline CD34 molecule Homo sapiens