Title : Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.

Pub. Date : 2000 Oct

PMID : 11043579






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We show that 17beta-estradiol activates Erk-1/-2 not only in MCF-7 cells, which express both estrogen receptor alpha (ER alpha) and ER beta, but also in SKBR3 breast cancer cells, which fail to express either receptor. Estradiol mitogen-activated protein kinase 3 Homo sapiens