Pub. Date : 2000 Sep
PMID : 11042671
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells. | Etoposide | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 2 | In addition, exposure of cells to etoposide resulted in decreased expression of Bcl-2 with reciprocal increase in Bax protein. | Etoposide | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 3 | Reduced glutathione or N-acetylcysteine, which could reduce ceramide formation by inhibiting sphingomyelinase activity, prevented C6 cells from etoposide-induced apoptosis through blockage of caspase-3 activation and change of the Bax/Bcl-2 ratio. | Etoposide | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 4 | Taken together, these results suggest that ceramide may function as a mediator of etoposide-induced apoptosis of C6 glioma cells, which induces increase in the Bax/Bcl-2 ratio followed by release of cytochrome c leading to caspases-9 and -3 activation. | Etoposide | BCL2 associated X, apoptosis regulator | Homo sapiens |