Title : NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.

Pub. Date : 2000 Oct

PMID : 11018074






1 Functional Relationships(s)
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1 These data strongly support the hypothesis that free radicals from NADPH oxidase in hepatic Kupffer cells play a predominant role in the pathogenesis of early alcohol-induced hepatitis by activating NF-kappaB, which activates production of cytotoxic TNF-alpha. Free Radicals nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus